Literature summary extracted from
Hornig, N.C.; Knowles, P.P.; McDonald, N.Q.; Uhlmann, F.
The dual mechanism of separase regulation by securin (2002), Curr. Biol., 12, 973-982.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
3.4.22.49 |
securin |
securin is required to support separase activity in anaphase |
Saccharomyces cerevisiae |
|
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
3.4.22.49 |
H1531A |
active site point mutation prevents Scc1 from being cleaved after binding |
Saccharomyces cerevisiae |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
3.4.22.49 |
securin |
inhibits the proteolytic activity of separase |
Saccharomyces cerevisiae |
|
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
3.4.22.49 |
nucleus |
while inhibiting separase, securin is able to promote nuclear accumulation of separase |
Saccharomyces cerevisiae |
5634 |
- |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.4.22.49 |
Saccharomyces cerevisiae |
- |
- |
- |